Virtual issue on Melanoma


Most recent reviews and articles on melanoma [2013][2012] [2011] [2010] [2009] [2008] [2007] [2006] [2005]

Recent Articles Published on Melanoma


Melanomas of unknown primary have a mutation profile consistent with cutaneous sun exposed melanoma
Ken Dutton-Regester, Hojabr Kakavand, Lauren G. Aoude, Mitchell S. Stark, Michael G. Gartside, Peter Johansson, Linda O'Connor, Cathy Lanagan, Varsha Tembe, Gulietta M. Pupo, Lauren Haydu, Christopher W. Schmidt, Graham J. Mann, John F. Thompson, Richard A. Scolyer and Nicholas K. Hayward

GLI2 cooperates with ZEB1 for transcriptional repression of CDH1 expression in human melanoma cells
Carole Y. Perrot, Cristèle Gilbert, Véronique Marsaud, Antonio Postigo, Delphine Javelaud and Alain Mauviel

Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy
Thomas Botton, Iwei Yeh, Tyrrell Nelson, Swapna S. Vemula, Alyssa Sparatta, Maria C. Garrido, Maryline Allegra, Stephane Rocchi, Philippe Bahadoran, Timothy H. McCalmont, Philip E. LeBoit, Elizabeth A. Burton, Gideon Bollag, Robert Ballotti and Boris C. Bastian

Radiation sensitivity and sensitization in melanoma
David Shahbazian, Ranjit S. Bindra, Harriet M. Kluger and Peter M. Glazer

Synergy between enzastaurin and doxorubicin in inducing melanoma apoptosis
Simona Romano, Giovanna Nappo, Gaetano Calì, Samuel Yu-Shan Wang, Stefania Staibano, Anna D'Angelillo, Ilardi Gennaro, Antonio Sorrentino, Anna Laura Di Pace, Maria Siano, Rita Bisogni and Maria Fiammetta Romano

TGF-β1 and TNF-α differentially regulate Twist1 mediated resistance towards BRAF/MEK inhibition in melanoma
Dinoop Ravindran Menon, Christian Wels, Ehsan Bonyadi Rad, Shripad Joshi, Heike Knausz, Johanne Lade-Keller, Johanna M. Brandner and Helmut Schaider

DNA repair and cell cycle checkpoint defects as drivers and therapeutic targets in melanoma
Sandra Pavey, Loredana Spoerri, Nikolas K. Haass and Brian Gabrielli

Notch signaling mediates melanoma–endothelial cell communication and melanoma cell migration
Jason D. Howard, Whei F. Moriarty, JinSeok Park, Katherine Riedy, Izabela P. Panova, Christine H. Chung, Kahp-Yang Suh, Andre Levchenko and Rhoda M. Alani

Paradoxical oncogenesis: are all BRAF inhibitors equal?
Alexander M. Menzies, Richard F. Kefford and Georgina V. Long

Identification of anaplastic lymphoma kinase break points and oncogenic mutation profiles in acral/mucosal melanomas
Hai-Tao Niu, Qi-Ming Zhou, Fang Wang, Qiong Shao, Yuan-Xiang Guan, Xi-Zhi Wen, Li-Zhen Chen, Qi-Sheng Feng, Wei Li, Yi-Xin Zeng and Xiao-Shi Zhang

Disturbed protein–protein interaction networks in metastatic melanoma are associated with worse prognosis and increased functional mutation burden
Sarah-Jane Schramm, Simone S. Li, Vivek Jayaswal, David C. Y. Fung, Anna E. Campain, Chi N. I. Pang, Richard A. Scolyer, Yee Hwa Yang, Graham J. Mann and Marc R. Wilkins

Evaluation of PAX3 genetic variants and nevus number
Zighereda Ogbah, Celia Badenas, Mark Harland, Joan A. Puig-Butille, Fay Elliot, Nuria Bonifaci, Elisabet Guino, Julie Randerson-Moor, May Chan, Mark M. Iles, Daniel Glass, Andrew A. Brown, Cristina Carrera, Isabel Kolm, Veronique Bataille, Timothy D. Spector, Josep Malvehy, Julia Newton-Bishop, Miquel A. Pujana, Tim Bishop and Susana Puig

Malignant and benign tumors associated with multiple primary melanomas: just the starting block for the involvement of MITF, PTEN and CDKN2A in multiple cancerogenesis?
Annamaria Pollio, Aldo Tomasi, Stefania Seidenari, Giovanni Pellacani, Monica Rodolfo, Simona Frigerio, Andrea Maurichi, Daniela Turchetti, Sara Bassoli, Cristel Ruini and Giovanni Ponti

Could pericytic mimicry represent another type of melanoma cell plasticity with embryonic properties?
Claire Lugassy, Bruno Péault, Madhuri Wadehra, Hynda K. Kleinman and Raymond L. Barnhill

Plasticity of melanoma in vivo: murine lesions resulting from Trp53, but not Cdk4 or Arf deregulation, display neural transdifferentiation
Herlina Y. Handoko, Glen M. Boyle, Blake Ferguson, H. Konrad Muller, H. Peter Soyer and Graeme J. Walker

KIT, NRAS, and BRAF mutations in nail apparatus melanoma
E. Dika, A. Altimari, A. Patrizi, E. Gruppioni, M. Fiorentino, B. M. Piraccini, C. Misciali, A. Barisani and P. A. Fanti

Melanoma inhibitory activity promotes melanoma development through activation of YBX1
Rainer Schmid, Katharina Meyer, Rainer Spang, Birgit Schittek and Anja-Katrin Bosserhoff

Development and characterization of a clinically relevant mouse model of melanoma brain metastasis
Amr Morsi, Avital Gaziel-Sovran, William Cruz-Munoz, Robert S. Kerbel, John G. Golfinos, Eva Hernando and Youssef Z. Wadghiri

DNA repair variants, indoor tanning, and risk of melanoma
Salina M. Torres, Li Luo, Jenna Lilyquist, Christine A. Stidley, Kristina Flores, Kirsten A. M. White, Esther Erdei, Melissa Gonzales, Susan Paine, Rachel I. Vogel, DeAnn Lazovich and Marianne Berwick

Nanomechanical analysis of pigmented human melanoma cells
Michal Sarna, Andrzej Zadlo, Anna Pilat, Magdalena Olchawa, Paraskevi Gkogkolou, Kvetoslava Burda, Markus Böhm and Tadeusz Sarna

T cell immunotherapy for melanoma from bedside to bench to barn and back: how conceptual advances in experimental mouse models can be translated into clinical benefit for patients (pages 441–456)
Thomas Tüting

Ret transgenic mouse model of spontaneous skin melanoma: focus on regulatory T cells (pages 457–463)
Viktor Umansky and Alexandra Sevko

Targeting melanoma by small molecules: challenges ahead (pages 464–469)
Rizwan Haq and David E. Fisher

Effects of BRAF inhibitors on human melanoma tissue before treatment, early during treatment, and on progression (pages 499–508)
Georgina V. Long, James S. Wilmott, Lauren E. Haydu, Varsha Tembe, Raghwa Sharma, Helen Rizos, John F. Thompson, Julie Howle, Richard A. Scolyer and Richard F. Kefford

Selective RAF inhibitor impairs ERK1/2 phosphorylation and growth in mutant NRAS, vemurafenib-resistant melanoma cells (pages 509–517)
Kaitlyn Le, Erik S. Blomain, Ulrich Rodeck and Andrew E. Aplin

Secondary c-Kit mutations confer acquired resistance to RTK inhibitors in c-Kit mutant melanoma cells (pages 518–526)
Jason R. Todd, Therese M. Becker, Richard F. Kefford and Helen Rizos

MERTK controls melanoma cell migration and survival and differentially regulates cell behavior relative to AXL (pages 527–541)
Kathryn A. Tworkoski, James T. Platt, Antonella Bacchiocchi, Marcus Bosenberg, Titus J. Boggon and David F. Stern

Genome-wide promoter methylation analysis identifies epigenetic silencing ofMAPK13 in primary cutaneous melanoma (pages 542–554)
Linda Gao, Marjon A. Smit, Joost J. van den Oord, Jelle J. Goeman, Els M. E. Verdegaal, Sjoerd H. van der Burg, Marguerite Stas, Samuel Beck, Nelleke A. Gruis, Cornelis P. Tensen, Rein Willemze, Daniel S. Peeper and Remco van Doorn

E-cadherin determines Caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells (pages 555–570)
Lorena Lobos-González, Lorena Aguilar, Jorge Diaz, Natalia Diaz, Hery Urra, Vicente A. Torres, Veronica Silva, Christopher Fitzpatrick, Alvaro Lladser, Keith S. Hoek, Lisette Leyton and Andrew F. G. Quest

Differential expression and tumor necrosis factor-mediated regulation of TNFRSF11b/osteoprotegerin production by human melanomas (pages 571–579)
Janine L. Oliver, Matthew P. Alexander, Allison G. Norrod, Irene M. Mullins and David W. Mullins

Chk1 is essential for the development of murine epidermal melanocytes (pages 580–585)
Joanne Smith, Lionel Larue and David A. Gillespie

Resistance to cisplatin-induced cell death conferred by the activity of organic anion transporting polypeptides (OATP) in human melanoma cells (pages 592–596)
Françoise Silvy, Jean-Claude Lissitzky, Nadine Bruneau, Nathalie Zucchini, Jean-François Landrier, Dominique Lombardo and Patrick Verrando

The Ludwig Institute for Cancer Research Melbourne Melanoma Cell Line Panel(pages 597–600)
Andreas Behren, Matthew Anaka, Pu-Han Lo, Laura J. Vella, Ian D. Davis, Jenny Catimel, Tracy Cardwell, Craig Gedye, Christopher Hudson, Rodica Stan and Jonathan Cebon

Meeting report from the Society for Melanoma Research 2012 Congress, Hollywood, California (pages E1–E7)
R. S. Lo, A. Ribas, G. V. Long, R. Ballotti, M. Berger, H. Willy, G. T. Gibney, M. Bosenberg, E. Bernstein, J. Villanueva and K. S. M. Smalley

Meeting report: The future of preclinical mouse models in melanoma treatment is now (pages E8–E14)
Glenn Merlino, Keith Flaherty, Nicolas Acquavella, Chi-Ping Day, Andrew Aplin, Sheri Holmen, Suzanne Topalian, Terry Van Dyke and Meenhard Herlyn

1. RhoJ Modulates Melanoma Invasion by Altering Actin Cytoskeletal Dynamics
Hsiang Ho, Amelia Soto Hopkin, Rubina Kapadia, Priya Vasudeva, Jonathan Schilling and Anand K. Ganesan

Senescence evasion in melanoma progression: uncoupling of DNA-damage signaling from p53 activation and p21 expression
Alastair D. MacKenzie Ross, Martin G. Cook, Heung Chong, Mehnaz Hossain, Hardev S. Pandha and Dorothy C. Bennett

Class II-specific histone deacetylase inhibitors MC1568 and MC1575 suppress IL-8 expression in human melanoma cells
I. Venza, M. Visalli, R. Oteri, M. Cucinotta, D Teti and M. Venza

Immunosuppression in inflammatory melanoma: can it be resisted by adoptively transferred T cells?
Nathalie Auphan-Anezin, Grégory Verdeil, Magali Grange, Saïdi M. Soudja, Maria Wehbe, Michel Buferne, Amandine Mas and Anne-Marie Schmitt-Verhulst

Circulating CD4 + CD25 high CD127 low regulatory T cells are an independent predictor of advanced melanoma
T. Gambichler, M. Bindsteiner, S. Höxtermann, S. Terras and A. Kreuter

Prevalence of germline BAP1 mutation in a population-based sample of uveal melanoma cases
Lauren G. Aoude, Claire M. Vajdic, Anne Kricker, Bruce Armstrong and Nicholas K. Hayward

Prevalence of the E318K MITF germline mutation in Italian melanoma patients: associations with histological subtypes and family cancer history
P. Ghiorzo, L. Pastorino, P. Queirolo, W. Bruno, M. G. Tibiletti, S. Nasti, V. Andreotti, Genoa Pancreatic Cancer Study Group, B. Bressac-de Paillerets and G. Bianchi Scarrà

The use of photodynamic therapy in the treatment of lentigo maligna
Allan Karam, Marlène Simon, Gilles Lemasson and Laurent Misery

Covering the bases: loss of 5-hydroxymethylcytosine in melanoma
Skirmantas Kriaucionis

Vitamin D and melanoma incidence and mortality
Marianne Berwick and Eszter O. Erdei

Emerging molecular targets in melanoma invasion and metastasis
Jose L. Orgaz and Victoria Sanz-Moreno

Genetic variation at KIT locus may predispose to melanoma
Agnes Bourillon, Hui-Han Hu, Gilles Hetet, Jean-Jacques Lacapere, Jocelyne André, Vincent Descamps, Nicole Basset-Seguin, Zighereda Ogbah, Susana Puig, Philippe Saiag, Martine Bagot, Armand Bensussan, Bernard Grandchamp, Nicolas Dumaz and Nadem Soufir

Identification of unique sensitizing targets for anti-inflammatory CDDO-Me in metastatic melanoma by a large-scale synthetic lethal RNAi screening
Yong Qin, Wuguo Deng, Suhendan Ekmekcioglu and Elizabeth A. Grimm

1. Linking aMSH with PPAR? in B16-F10 melanoma
Vittoria Maresca, Enrica Flori, Emanuela Camera, Barbara Bellei, Nicaela Aspite, Matteo Ludovici, Caterina Catricalà, Giorgia Cardinali and Mauro Picardo

A unique gender difference in early onset melanoma implies that in addition to ultraviolet light exposure other causative factors are important
Feng Liu, Leona Bessonova, Thomas H. Taylor, Argyrios Ziogas, Frank L. Meyskens Jr. and Hoda Anton-Culver Article first published online:

Inhibition of melanoma development in the Nras(Q61K)::Ink4a-/- mouse model by the small molecule BI-69A11 
Yongmei Feng, Eric Lau, Marzia Scortegagna, Chelsea Ruller, Surya K. De, Elisa Barile, Stan Krajewski, Pedro Aza-Blanc, Roy Williams, Anthony B. Pinkerton, Michael Jackson, Lynda Chin, Maurizio Pellecchia, Marcus Bosenberg and Ze'ev A. Ronai

Nicotinamide phosphoribosyltransferase (NAMPT) is over-expressed in melanoma lesions
Elena Maldi, Cristina Travelli, Antonio Caldarelli, Nicolò Agazzone, Sara Cintura, Ubaldina Galli, Maria Scatolini, Paola Ostano, Benedetta Miglino, Giovanna Chiorino, Renzo Boldorini and Armando A. Genazzani

Reduced expression of nuclear Dicer correlates with melanoma progression
Seyed M. Jafarnejad, Cecilia Sjoestroem, Gholamreza S. Ardekani, Magdalena Martinka and Gang Li


A unique gender difference in early onset melanoma implies that in addition to ultraviolet light exposure other causative factors are important
Feng Liu, Leona Bessonova, Thomas H. Taylor, Argyrios Ziogas, Frank L. Meyskens and Hoda Anton-Culver

Prevalence of germline BAP1 mutation in a population-based sample of uveal melanoma cases
Lauren G. Aoude, Claire M. Vajdic, Anne Kricker, Bruce Armstrong and Nicholas K. Hayward

The use of photodynamic therapy in the treatment of lentigo maligna
Allan Karam, Marlène Simon, Gilles Lemasson and Laurent Misery

CXCR7, not CXCR4, mediates SDF1-induced melanocyte migration
Eunkyung Lee, Jiyeon Han, Kwangmi Kim, Hyunjung Choi, Eun-Gyung Cho and Tae Ryong Lee

Nicotinamide phosphoribosyltransferase (NAMPT) is over-expressed in melanoma lesions
Elena Maldi, Cristina Travelli, Antonio Caldarelli, Nicolò Agazzone, Sara Cintura, Ubaldina Galli, Maria Scatolini, Paolo Ostano, Benedetta Miglino, Giovanna Chiorino, Renzo Boldorini and Armando Genazzani

Reduced expression of nuclear Dicer correlates with melanoma progression
Seyed Mehdi Jafarnejad, Cecilia Sjoestroem, Gholamreza Safaee Ardekani, Magdalena Martinka and Gang Li

High UVA exposure from sunbeds
Lill Tove N. Nilsen, Tommy Nakken Aalerud, Merete Hannevik and Marit B. Veierød

Melanoma back in the UVA spotlight
David Mitchell

Randy Lomax - the passionate melanoma advocate and champion of the Melanoma Research Foundation
Meenhard Herlyn

Melanoma-Derived Conditioned Media Efficiently Induce the Differentiation of Monocytes to Macrophages that Display a Highly Invasive Gene Signature
Tao Wang, Yingbin Ge, Min Xiao, Alfonso Lopez-Coral, Rikka Azuma, Rajasekharan Somasundaram, Gao Zhang, Zhi Wei, Xiaowei Xu, Frank J. Rauscher III, Meenhard Herlyn and Russel E. Kaufman

Inflammasome polymorphisms confer susceptibility to sporadic malignant melanoma
Deepti Verma, Cecilia Bivik, Ensieh Farahani, Ingrid Synnerstad, Mats Fredrikson, Charlotta Enerbäck, Inger Rosdahl and Peter Söderkvist

Constitutive gray hair in mice induced by melanocyte-specific deletion of c-Myc
Irina Pshenichnaya, Karine Schouwey, Marzia Armaro, Lionel Larue, Paul S. Knoepfler, Robert N. Eisenman, Andreas Trumpp, Véronique Delmas and Friedrich Beermann

Glutamatergic signaling in cellular transformation
Jessica L. F. Teh and Suzie Chen

Systematic classification of melanoma cells by phenotype-specific gene expression mapping
Daniel S. Widmer, Phil F. Cheng, Ossia M. Eichhoff, Benedetta C. Belloni, Marie C. Zipser, Natalie C. Schlegel, Delphine Javelaud, Alain Mauviel, Reinhard Dummer and Keith S. Hoek

Proteasome inhibition and ROS generation by 4-nerolidylcatechol induces melanoma cell death
Carla A. Brohem, Renato R. Massaro, Manoela Tiago, Camila E. Marinho, Miriam G. Jasiulionis, Rebeca L. de Almeida, Diogo P. Rivelli, Renata C. Albuquerque, Tiago F. de Oliveira, Ana P. de Melo Loureiro, Sabrina Okada, María S. Soengas, Silvia B. de Moraes Barros and Silvya S. Maria-Engler

Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells
Fabian V. Filipp, David A. Scott, Ze’ev A. Ronai, Andrei L. Osterman and Jeffrey W. Smith

Inherited variants in the MC1R gene and survival from cutaneous melanoma: a BioGenoMEL study
John R. Davies, Juliette Randerson-Moor, Kairen Kukalizch, Mark Harland, Rajiv Kumar, Srinivasan Madhusudan, Eduardo Nagore, Johan Hansson, Veronica Höiom, Paola Ghiorzo, Nelleke A. Gruis, Peter A. Kanetsky, Judith Wendt, Dace Pjanova, Susana Puig, Philippe Saiag, Dirk Schadendorf, Nadem Soufir, Ichiro Okamoto, Paul Affleck, Zaida García-Casado, Zighereda Ogbah, Aija Ozola, Paola Queirolo, Antje Sucker, Jennifer H. Barrett, Remco van Doorn, D. Timothy Bishop and Julia Newton-Bishop

Development of five new melanoma low passage cell lines representing the clinical and genetic profile of their tumors of origin
Eleazar Vega-Saenz de Miera, Erica B. Friedman, Holly S. Greenwald, Mary A. Perle and Iman Osman

FOXP3 is not mutated in human melanoma
BeeShin Tan, Andreas Behren, Matthew Anaka, Laura Vella, Jonathan Cebon, John M. Mariadason and Weisan Chen

Unraveling the melanoma pathogenome
Glenn Merlino

Reviewing the somatic genetics of melanoma: from current to future analytical approaches
Ken Dutton-Regester and Nicholas K. Hayward

Delving into somatic variation in sporadic melanoma
Vijay Walia, Euphemia W. Mu, Jimmy C. Lin and Yardena Samuels

The genetics of uveal melanoma: an emerging framework for targeted therapy
J. William Harbour

Genetic and molecular characterization of uveal melanoma cell lines
K. G. Griewank, X. Yu, J. Khalili, M. M. Sozen, K. Stempke-Hale, C. Bernatchez, S. Wardell, B. C. Bastian and S. E. Woodman

Increased levels of DUSP6 phosphatase stimulate tumourigenesis in a molecularly distinct melanoma subtype
Weiling Li, Liang Song, Ann-Marie Ritchie and David W. Melton

Functional expression of voltage-gated calcium channels in human melanoma
A. Das, C. Pushparaj, N. Bahí, A. Sorolla, J. Herreros, R. Pamplona, R. Vilella, X. Matias-Guiu, R. M. Martí and C. Cantí

Elevated expression of Rad18 regulates melanoma cell proliferation
Ronald P.C. Wong, Almass-houd Aguissa-Touré, Aijaz A. Wani, Shahram Khosravi, Michal Martinka, Magdalena Martinka and Gang Li

Genome-wide association studies in melanoma: off to a good start
Hye Kyung Kim and Stephen J. Chanock

Site-dependent actinic skin damage as risk factor for melanoma in a central European population
Judith Wendt, Oliver Schanab, Michael Binder, Hubert Pehamberger and Ichiro Okamoto

Duplication of CXC chemokine genes on chromosome 4q13 in a melanoma-prone family
Xiaohong R. Yang, Kevin Brown, Maria T. Landi, Paola Ghiorzo, Celia Badenas, Mai Xu, Nicholas K. Hayward, Donato Calista, Giorgio Landi, William Bruno, Giovanna Bianchi-Scarrà, Paula Aguilera, Susana Puig, Alisa M. Goldstein and Margaret A. Tucker

Targeting sphingosine kinase-1 to inhibit melanoma
SubbaRao V. Madhunapantula, Jeremy Hengst, Raghavendra Gowda, Todd E. Fox, Jong K. Yun and Gavin P. Robertson

Carcinogen treatment in mouse selectively expressing activated N-RasQ61K in melanocytes recapitulates metastatic cutaneous melanoma development
Emmanuel Contassot, Dragana Jankovic, Prisca Schuler, Olivier Preynat-Seauve, Samuel Gehrke, Katrin Kerl, Friedrich Beermann and Lars E. French

New dream team for melanoma therapy
Meenhard Herlyn

En route to a new in vivo diagnostic of malignant pigmented melanoma
Matthias Scholz, Goran Stankovic, Christian Scholz, Dieter Leupold, Susanne Buder, Peter Kohl, Reinhold Eichhorn, Markus Stuecker and Klaus Hoffmann

Identification of differentially expressed genes in matched formalin-fixed paraffin-embedded primary and metastatic melanoma tumor pairs
Rosalyn Jewell, Angana Mitra, Caroline Conway, James Iremonger, Christy Walker, Floor de Kort, Martin Cook, Andy Boon, Valerie Speirs and Julia Newton-Bishop

Highly penetrant melanoma in a zebrafish model is independent of ErbB3b signaling
Cristina Santoriello, Viviana Anelli, Elisa Alghisi and Marina Mione

Identification of a melanocyte-specific, microphthalmia-associated transcription factor-dependent regulatory element in the intronic duplication causing hair greying and melanoma in horses
Elisabeth Sundström, Anna Z. Komisarczuk, Lin Jiang, Anna Golovko, Pavla Navratilova, Silke Rinkwitz, Thomas S. Becker and Leif Andersson

Coat color dilution in mice because of inactivation of the melanoma antigen MART-1
Iraz T. Aydin, Edith Hummler, Nico P. M. Smit and Friedrich Beermann

Inhibition of coding region determinant binding protein sensitizes melanoma cells to chemotherapeutic agents
Evisabel A. Craig and Vladimir S. Spiegelman

Melanoma cells in distinct growth phases retain specific invasive qualities during brain metastasis in vivo
Jelena Krochmann, Tobias Sinnberg, Friedegund Meier, Claus Garbe and Christian Busch

Meeting report from the 2011 international melanoma congress, Tampa, Florida
Keiran S. M. Smalley, Andrew E. Aplin, Keith T. Flaherty, Christoph Hoeller, Anja K. Bosserhoff, Nikolas K. Haass, Marcus Bosenberg, Antoni Ribas, Raymond Barnhill, Ragini Kudchadkar and Jane L. Messina


Induction of senescence in melanoma: thinking outside the cell
Narendra Wajapeyee and Michael R. Green

Serine biosynthesis: fuel for the melanoma cell growth engine
Stephen G. Dann and Robert T. Abraham

A DUB for MITF: no myth, some dubiety
Serge Y. Fuchs

The melanomas: a synthesis of epidemiological, clinical, histopathological, genetic, and biological aspects, supporting distinct subtypes, causal pathways, and cells of origin
David C. Whiteman, William J. Pavan and Boris C. Bastian

Front seat and back seat drivers of melanoma metastasis
Lionel Larue and Irwin Davidson

The role of mitogen- and stress-activated protein kinase pathways in melanoma
Pablo Lopez-Bergami

Embryonic stem-cell-preconditioned microenvironment induces loss of cancer cell properties in human melanoma cells
Myoung Ok Kim, Sung-Hyun Kim, Naomi Oi, Mee Hyun Lee, Dong Hoon Yu, Dong Joon Kim, Eun Jin Cho, Ann M. Bode, Yong-Yeon Cho, Tim G. Bowden and Zigang Dong

GLI2 and M-MITF transcription factors control exclusive gene expression programs and inversely regulate invasion in human melanoma cells
Delphine Javelaud, Vasileia-Ismini Alexaki, Marie-Jeanne Pierrat, Keith S. Hoek, Sylviane Dennler, Leon Van Kempen, Corine Bertolotto, Robert Ballotti, Simon Saule, Véronique Delmas and Alain Mauviel

Constitutive activation of the ETS-1-miR-222 circuitry in metastatic melanoma
Gianfranco Mattia, M. Cristina Errico, Federica Felicetti, Marina Petrini, Lisabianca Bottero, Luisa Tomasello, Paolo Romania, Alessandra Boe, Patrizia Segnalini, Antonio Di Virgilio, Mario P. Colombo and Alessandra Carè

Identification of DNA repair gene Ercc1 as a novel target in melanoma
Liang Song, Ann-Marie Ritchie, Ewan M. McNeil, Weiling Li and David W. Melton

Sorting through the many opportunities for melanoma therapy
Meenhard Herlyn and Jessie Villanueva

Melanoma response and resistance – taking it to the tumor bank
John M. Kirkwood

Pitfalling in nanomedical targeting of melanoma: a ‘clinical’ case of misdelivered RNAi
Roberto Perris, Cinzia Borghese and Gaetano Magro

General strategy to analyse melanoma in mice
Stuart J. Gallagher, Flavie Luciani, Irina Berlin, Florian Rambow, Gwendoline Gros, Delphine Champeval, Véronique Delmas and Lionel Larue

2011 International Melanoma Congress

If you can’t beat me, join me: collaborating oncogenes circumventing senescence and causing cancer
Patricia A. Possik and Daniel S. Peeper

Targeting leucine addiction and autophagy in melanoma
Maria T. Diaz-Meco

Melanoma researchers have a reason to GRIN: melanoma yields more of its secrets to exome sequencing
Paul Meltzer

The pleiotropic roles of autophagy regulators in melanogenesis
Hsiang Ho and Anand K. Ganesan

Differential LEF1 and TCF4 expression is involved in melanoma cell phenotype switching
Ossia M. Eichhoff, Ashani Weeraratna, Marie C. Zipser, Laurence Denat, Daniel S. Widmer, Mai Xu, Lydia Kriegl, Thomas Kirchner, Lionel Larue, Reinhard Dummer and Keith S. Hoek

Suppression of [alpha]5 gene expression is closely related to the tumorigenic properties of uveal melanoma cell lines
Solange Landreville, François Vigneault, Marjorie-Allison Bergeron, Steeve Leclerc, Manon Gaudreault, Mohib Morcos, Frédéric Mouriaux, Christian Salesse and Sylvain L. Guérin

Expression of human endogenous retrovirus K is stimulated by ultraviolet radiation in melanoma
Oliver Schanab, Johannes Humer, Andreas Gleiss, Mario Mikula, Sanda Sturlan, Susanne Grunt, Ichiro Okamoto, Thomas Muster, Hubert Pehamberger and Andrea Waltenberger

Clinical outcome and pathological features associated with NRAS mutation in cutaneous melanoma
Bianca Devitt, Wendy Liu, Renato Salemi, Rory Wolfe, John Kelly, Chin-Yuan Tzen, Alexander Dobrovic and Grant McArthur

Epac1 promotes melanoma metastasis via modification of heparan sulfate
Erdene Baljinnyam, Masanari Umemura, Mariana S. De Lorenzo, Mizuka Iwatsubo, Suzie Chen, James S. Goydos and Kousaku Iwatsubo

Botanicals for the prevention and treatment of cutaneous melanoma
Deeba N. Syed and Hasan Mukhtar

Effective inhibition of melanoma by BI-69A11 is mediated by dual targeting of the AKT and NF-κB pathways
Yongmei Feng, Elisa Barile, Surya K. De, John L. Stebbins, Apple Cortez, Pedro Aza-Blanc, Jessie Villanueva, Meenhard Heryln, Stan Krajewski, Maurizio Pellecchia, Ze’ev A. Ronai and Gary G. Chiang

The phosphatidyl inositol 3-kinase pathway is central to the pathogenesis of Kit-activated melanoma
Ruixia Liang, Andrea R. Wallace, Dirk Schadendorf and Brian P. Rubin

UV-tanning behavior: a problem that doesn’t go away
David E. Fisher

Contribution of susceptibility gene variants to melanoma risk in families from the Veneto region of Italy
Chiara Menin, Antonella Vecchiato, Maria Chiara Scaini, Lisa Elefanti, Gloria Funari, Gian Luca De Salvo, Monica Quaggio, Silvia Tognazzo, Simona Agata, Silvia Dalla Santa, Marco Montagna, Mauro Alaibac, Vanna Chiarion-Sileni and Emma D’Andrea

FoxP3 expression on melanoma cells is related to early visceral spreading in melanoma patients treated by electrochemotherapy
Pietro Quaglino, Simona Osella-Abate, Federica Marenco, Tiziana Nardò, Chiara Gado, Mauro Novelli, Paola Savoia and Maria Grazia Bernengo

Dermis-derived stem cells: a source of epidermal melanocytes and melanoma?
Susan E. Zabierowski, Mizuho Fukunaga-Kalabis, Ling Li and Meenhard Herlyn

ABCB1 identifies a subpopulation of uveal melanoma cells with high metastatic propensity
Solange Landreville, Olga A. Agapova, Zachary T. Kneass, Christian Salesse and J. William Harbour

Receptor tyrosine kinases and their activation in melanoma
David J. Easty, Steven G. Gray, Kenneth J. O’Byrne, Dearbhaile O’Donnell and Dorothy C. Bennett

Junctional adhesion molecules are required for melanoma cell lines transendothelial migration in vitro
Stephanie Ghislin, Dorian Obino, Sandrine Middendorp, Nicole Boggetto, Catherine Alcaide-Loridan and Frederique Deshayes

Constitutive Smad linker phosphorylation in melanoma: a mechanism of resistance to transforming growth factor-β-mediated growth inhibition
Karine A. Cohen-Solal, Kim T. Merrigan, Joseph L.-K. Chan, James S. Goydos, Wenjin Chen, David J. Foran, Fang Liu, Ahmed Lasfar and Michael Reiss

Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor
Glen M. Boyle, Susan L. Woods, Vanessa F. Bonazzi, Mitchell S. Stark, Elke Hacker, Lauren G. Aoude, Ken Dutton-Regester, Anthony L. Cook, Richard A. Sturm and Nicholas K. Hayward

MicroRNA-155 targets the SKI gene in human melanoma cell lines
Lauretta Levati, Elena Pagani, Sveva Romani, Daniele Castiglia, Eugenia Piccinni, Claudia Covaciu, Patrizia Caporaso, Sergio Bondanza, Francesca R. Antonetti, Enzo Bonmassar, Fabio Martelli, Ester Alvino and Stefania D’Atri

Regulation of NR4A nuclear receptor expression by oncogenic BRAF in melanoma cells
Aaron G. Smith, Wen Lim, Michael Pearen, George E. O. Muscat and Richard A. Sturm

Sunbeds and sunlamps: who used them and their risk for melanoma
Thomas R. Fears, Richard W. Sagebiel, Allan Halpern, David E. Elder, Elizabeth A. Holly, DuPont Guerry IV and Margaret A. Tucker

Inter-observer concordance for the recognition of angiotropism in human melanoma
Raymond L. Barnhill, Klaus J. Busam, Lynn From, Martine Bagot, Claire Lugassy and Marianne Berwick

Uveal Melanoma and GNA11 Mutations: a new piece added to the puzzle
Ahmad Besaratinia, Gerd P. Pfeifer

Melanocytes and melanoma: hooked on elongation
James A. Lister

Mind the BAP
Andrew E. Aplin and Takami Sato

Stress-sensing toll-like receptor as a driver of angiogenesis
Xiang-Yang Wang, Devanand Sarkar and Paul B. Fisher

Receptor tyrosine kinases and their activation in melanoma
David J. Easty, Steven G. Gray, Kenneth J. O’Byrne, Dearbhaile O’Donnell, Dorothy C. Bennett

The deceptive nature of UVA tanning versus the modest protective effects of UVB tanning on human skin
Yoshinori Miyamura, Sergio G. Coelho, Kathrin Schlenz, Jan Batzer, Christoph Smuda, Wonseon Choi, Michaela Brenner, Thierry Passeron, Guofeng Zhang, Ludger Kolbe, Rainer Wolber and Vincent J. Hearing

Is DHICA the key to dopachrome tautomerase and melanocyte functions?
Lucia Panzella, Alessandra Napolitano and Marco d’Ischia

Parsing out the complexity of RAF inhibitor resistance
Martin McMahon

In vitro studies of dasatinib, its targets and predictors of sensitivity
Lucia B. Jilaveanu, Christopher R. Zito, Saadia A. Aziz, Ashok Chakraborty, Michael A. Davies, Robert L. Camp, David L. Rimm, Arkadiusz Dudek, Mario Sznol and Harriet M. Kluger

Illuminating progression: tracking melanoma metastasis in a gene therapy setting
Chi-Ping Day and Glenn Merlino

(Mela)statin’ the not so obvious: tumor suppressor hidden in intron
Ashley M. Poenitzsch, Vijayasaradhi Setaluri and Vladimir S. Spiegelman

Unwelcome guests: macrophages promote UV-induced melanoma
William E. Damsky and Marcus Bosenberg

Integrins: versatile receptors controlling melanocyte adhesion, migration and proliferation
Perrine Pinon and Bernhard Wehrle-Haller

Advances in melanoma senescence and potential clinical application
Sandy Giuliano, Mickaël Ohanna, Robert Ballotti and Corine Bertolotto

Wnt/β-catenin signaling is stimulated by hormone in melanoma and melanocyte cells: implication in cell differentiation
Barbara Bellei, Angela Pitisci, Caterina Catricalà, Lionel Larue and Mauro Picardo

A proliferative melanoma cell phenotype is responsive to RAF/MEK inhibition independent of BRAF mutation status
Marie C. Zipser, Ossia M. Eichhoff, Daniel S. Widmer, Natalie C. Schlegel, Nicola L. Schoenewolf, Darrin Stuart, Weihua Liu, Humphrey Gardner, Paul D. Smith, Paolo Nuciforo, Reinhard Dummer and Keith S. Hoek

Immune reactions in benign and malignant melanocytic lesions: lessons for immunotherapy
R. Speeckaert, N. van Geel, K. V. Vermaelen, J. Lambert, M. Van Gele, M. M. Speeckaert and L. Brochez

BRAF mutations in cutaneous melanoma are independently associated with age, anatomic site of the primary tumor, and the degree of solar elastosis at the primary tumor site
Jürgen Bauer, Petra Büttner, Rajmohan Murali, Ichiro Okamoto, Nicholas A. Kolaitis, Maria T. Landi, Richard A. Scolyer and Boris C. Bastian

DNA-methylation profiling distinguishes malignant melanomas from benign nevi
Kathleen Conway, Sharon N. Edmiston, Zakaria S. Khondker, Pamela A. Groben, Xin Zhou, Haitao Chu, Pei Fen Kuan, Honglin Hao, Craig Carson, Marianne Berwick, David W. Olilla and Nancy E. Thomas

Recombinant human arginase inhibits the in vitro and in vivo proliferation of human melanoma by inducing cell cycle arrest and apoptosis
Tin-Lun Lam, Gabriel K. Y. Wong, Ho-Yin Chow, Hiu-Chi Chong, Tsz-Lung Chow, Sui-Yi Kwok, Paul N. M. Cheng, Denys N. Wheatley, Wai-Hung Lo and Yun-Chung Leung

A zebrafish model for nevus regeneration
Jennifer Richardson, Zhiqiang Zeng, Craig Ceol, Marina Mione, Ian J. Jackson and E. Elizabeth Patton
The cadherin switch in melanoma instigated by HGF is mediated through epithelial–mesenchymal transition regulators
Petra Koefinger, Christian Wels, Shripad Joshi, Sabine Damm, Elisabeth Steinbauer, Christine Beham-Schmid, Sasa Frank, Helmut Bergler and Helmut Schaider

V559A and N822I double KIT mutant melanoma with predictable response to imatinib?
Kevin McDonnell, Bryan Betz, Douglas Fullen and Christopher D. Lao

A genetically engineered mouse model with inducible GFP expression in melanocytes
M. Raza Zaidi, Thomas J. Hornyak and Glenn Merlino

Melanoma and DNA damage from a distance (farstander effect)  
Shobhan Gaddameedhi and Aziz Sancar

Red hair or not – reassessment of melanoma risk among CDKN2A carriers
Marianne Berwick

Is UV-induced mutation formation in melanocytes different from other skin cells?
Thomas M. Rünger

Melanoma and viagra: an unexpected connection
Devarati Mitra, Kathleen C. Robinson and David E. Fisher

Uveal Melanoma and GNA11 Mutations: a new piece added to the puzzle
Ahmad Besaratinia and Gerd P. Pfeifer

Meeting report from the 7th International Melanoma Congress, Sydney, November, 2010  
P. Hersey, K. S. M. Smalley, A. Weeraratna, M. Bosenberg, X. D. Zhang, N. K. Haass, E. Paton, G. Mann and R. A. Scolyer

Taking stock of translational research in melanoma at the 2010 Society for Melanoma Research Congress
Keith T. Flaherty

Melanoma: is hair the root of the problem?  
Angela M. Gomez Garcia, Christine E. McLaren and Frank L. Meyskens Jr.

Different types of DNA damage play different roles in the etiology of sunlight-induced melanoma
David L. Mitchell and André A. Fernandez

Post-transcriptional regulation controlled by E-cadherin is important for c-Jun activity in melanoma  
B. Spangler, L. Vardimon, A. K. Bosserhoff and S. Kuphal

Plexin B1 inhibits integrin-dependent pp125FAK and Rho activity in melanoma
Lindy McClelland, YuLin Chen, Joanne Soong, IHsin Kuo and Glynis Scott

Loss of Klotho during melanoma progression leads to increased filamin cleavage, increased Wnt5A expression, and enhanced melanoma cell motility  
Tura C. Camilli, Mai Xu, Michael P. O’Connell, Bonnie Chien, Brittany P. Frank, Sarah Subaran, Fred E. Indig, Patrice J. Morin, Stephen M. Hewitt and Ashani T. Weeraratna

Clinical relevance of SKP2 alterations in metastatic melanoma
Amy E. Rose, Guimin Wang, Douglas Hanniford, Stefano Monni, Ting Tu, Richard L. Shapiro, Russell S. Berman, Anna C. Pavlick, Michele Pagano, Farbod Darvishian, Madhu Mazumdar, Eva Hernando and Iman Osman

Quantitative expression profiling of G-protein-coupled receptors (GPCRs) in metastatic melanoma: the constitutively active orphan GPCR GPR18 as novel drug target
Y. Qin, E. M. E. Verdegaal, M. Siderius, J. P. Bebelman, M. J. Smit, R. Leurs, R. Willemze, C. P. Tensen and S. Osanto

The p53/p21Cip1/ Waf1 pathway mediates the effects of SPARC on melanoma cell cycle progression  
Nina Fenouille, Guillaume Robert, Mélanie Tichet, Alexandre Puissant, Maeva Dufies, Stéphane Rocchi, Jean-Paul Ortonne, Marcel Deckert, Robert Ballotti and Sophie Tartare-Deckert

Seasonal variation in the month of birth in teenagers and young adults with melanoma suggests the involvement of early-life UV exposure
Nermine O. Basta, Peter W. James, Alan W. Craft and Richard J. Q. McNally

mTOR pathway activation in cutaneous melanoma is associated with poorer prognosis characteristics
H. Pópulo, P. Soares, A. Faustino, A. S. Rocha, P. Silva, F. Azevedo and J. M. Lopes


‘Going green’ against skin cancer
Mariam Malik and Stuart Yuspa

Of swords and ploughshares: immunosurveillance and inflammation in melanoma
Thomas Tüting

Oncogenic RAF: a brief history of time
David Solit and Neal Rosen

Cancer stem cells versus phenotype-switching in melanoma
Keith S Hoek and Colin R Goding

Genetic and morphologic features for melanoma classification
Sigrid M. C. Broekaert, Ritu Roy, Ichiro Okamoto, Joost Van Den Oord, Jürgen Bauer, Claus Garbe, Raymond L. Barnhill, Klaus J. Busam, Alistair J. Cochran, Martin G. Cook, David E. Elder, Stanley W. McCarthy, Martin C. Mihm, Dirk Schadendorf, Richard A. Scolyer, Alan Spatz and Boris C. Bastian

Differential roles of the pRb and Arf/p53 pathways in murine naevus and melanoma genesis
Blake Ferguson, H. Konrad Muller, Herlina Y. Handoko, Kiarash Khosrotehrani, Friedrich Beermann, Elke Hacker, H. Peter Soyer, Marcus Bosenberg and Graeme J. Walker

p53 prevents progression of nevi to melanoma predominantly through cell cycle regulation
Tamara Terzian, Enrique C. Torchia, Daisy Dai, Steven E. Robinson, Kazutoshi Murao, Regan A. Stiegmann, Victoria Gonzalez, Glen M. Boyle, Marianne Broome Powell, Pamela Pollock, Guillermina Lozano, William A. Robinson, Dennis R. Roop and Neil F. Box

Smad7 Restricts Melanoma Invasion by Restoring N-cadherin Expression and Establishing Heterotypic Cell-Cell Interactions In Vivo
Kyle A. DiVito, Valerie A. Trabosh, You-Shin Chen, Yu Chen, Chris Albanese, Delphine Javelaud, Alain Mauviel, Cynthia M. Simbulan-Rosenthal and Dean S. Rosenthal

Downregulation of SIK2 expression promotes the melanogenic program in mice
Nanao Horike, Ayako Kumagai, Yuko Shimono, Tomoko Onishi, Yumi Itoh, Tsutomu Sasaki, Kazuo Kitagawa, Osamu Hatano, Hiroaki Takagi, Teruo Susumu, Hiroshi Teraoka, Ken-ichi Kusano, Yasuo Nagaoka, Hidehisa Kawahara and Hiroshi Takemori

PLX4032, a Potent Inhibitor of the B-Raf V600E Oncogene, Selectively Inhibits V600E-positive Melanomas
John T. Lee, Ling Li, Patricia A. Brafford, Marcia Van Den Eijnden, Molly B. Halloran, Katrin Sproesser, Nikolas K. Haass, Keiran S.M. Smalley, James Tsai, Gideon Bollag and Meenhard Herlyn

The aryl hydrocarbon receptor (AHR), a novel regulator of human melanogenesis
Sandra Luecke, Maria Backlund, Bettina Jux, Charlotte Esser, Jean Krutmann and Agneta Rannug

Sunscreen prevention of melanoma in man and mouse
Heather L.P. Klug, Janet A. Tooze, Cari Graff-Cherry, Miriam R. Anver, Frances P. Noonan, Thomas R. Fears, Margaret A. Tucker, Edward C. De Fabo and Glenn Merlino

Melanoma cell-secreted soluble factor that stimulates ubiquitination and degradation of the interferon alpha receptor and attenuates its signaling
Wei-Chun HuangFu, Juan Qian, Chengbao Liu, Hallgeir Rui and Serge Y Fuchs

Decreased heme oxygenase-1 expression distinguishes human melanomas from melanocytic nevi
Sun A Jin, Jae-Jeong Park, Jee-Bum Lee, Seung-Chul Lee and Sook Jung Yun

Quantitative Measurement of Circulating Lymphoid-Specific Helicase (HELLS) Gene Transcript: Potential Serum Biomarker for Melanoma Metastasis
Hye-Eun Kim, James T. Symanowski, Erika E. Samlowski, Jason Gonzales and Byungwoo Ryu

Combined mass spectrometry- and immunohistochemistry-based approach to determine protein expression in archival melanoma – proof of principle
Karim Rezaul, Michael Murphy, Deborah H. Lundgren, Lori Wilson and David K. Han

Mouse melanoma models and cell lines
William E. Damsky Jr and Marcus Bosenberg

Melanoma Tissue Microarray (TMA) Cohort and Data Repository
David L. Rimm

Improved melanoma survival at last! Ipilimumab and a paradigm shift for immunotherapy
Thomas F. Gajewski
TRP-ing off the p53 apoptotic switch
Afshan Ahmed and Margaret Ashcroft

Genome-Wide Association Studies of Pigmentation and Skin Cancer: A Review and Meta-Analysis
MR Gerstenblith, J Shi, MT Landi

Dendritic cell vaccination in human melanoma: relationships between clinical effects and vaccine parameters 
Noriaki Nakai, Gunther Hartmann, Saburo Kishimoto, Norito Katoh

The evolving concept of ‘melano-miRs’– microRNAs in melanomagenesis
Daniel W. Mueller and Anja-Katrin Bosserhoff

The unfolded protein response in melanocytes: activation in response to chemical stressors of the endoplasmic reticulum and tyrosinase misfolding
Prashiela Manga, Sabina Bis, Kristen Knoll, Beremis Perez and Seth J. Orlow

Loss of nuclear receptor RXR in epidermal keratinocytes promotes the formation of Cdk4-activated invasive melanomas
Stephen Hyter, Gaurav Bajaj, Xiaobo Liang, Mariano Barbacid, Gitali Ganguli-Indra and Arup Kumar Indra
Autochthonous primary and metastatic melanomas in Hgf-Cdk4R24C mice evade T cell-mediated immune surveillance
Jennifer Landsberg, Evelyn Gaffal, Mira Cron, Judith Kohlmeyer, Marcel Renn, Thomas Tüting

Radiation-inducible human tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene therapy: a novel treatment for radioresistant uveal melanoma
Yixiong Zhou, Xin Song, Renbin Jia, Haibo Wang, Liyan Dai, Xiaofang Xu, Ping Gu, Shengfang Ge, Xianqun Fan

Melanoma stem cells – are there devils in the detail?
Mark Shackleton

Targeting GRP78 to enhance melanoma cell death 
S. Martin, D.S. Hill, J.C. Paton, A.W. Paton, M.A. Birch-Machin, P.E. Lovat, C.P.F. Redfern

The EphB4 receptor promotes the growth of melanoma cells expressing the ephrin-B2 ligand
Nai-Ying Yang, Pablo Lopez-Bergami, James S. Goydos, Dana Yip, Ameae M. Walker, Elena B. Pasquale, Iryna Ethell

A role for the JARID1B stem cell marker for continuous melanoma growth
Matthew Held, Marcus Bosenberg

Sox proteins in melanocyte development and melanoma.  
Melissa L. Harris, Laura L. Baxter, Stacie K. Loftus, William J. Pavan

Targeted delivery of NRASQ61R and Cre-recombinase to postnatal melanocytes induces melanoma in Ink4a/Arflox/lox mice 
Matthew W. VanBrocklin, James P. Robinson, Kristin J. Lastwika, Joseph D. Khoury, Sheri L. Holmen

Topoisomerase I amplification in melanoma is associated with more advanced tumours and poor prognosis
Denise Ryan, Mairin Rafferty, Shauna Hegarty, Patrick O' Leary, William Faller, Gabriela Gremel, Michael Bergqvist, Margret Agnarsdottir, Sara Strömberg, Caroline Kampf, Fredrik Pontén, Robert C. Millikan, Peter A. Dervan, William M. Gallagher

Apoptosis initiation and angiogenesis inhibition: melanoma targets for nanosecond pulsed electric fields 
Xinhua Chen, Juergen F. Kolb, R. James Swanson, Karl H. Schoenbach, Stephen J. Beebe

Cul1 expression is increased in early stages of human melanoma 
Guangdi Chen, Yabin Cheng, Magdalena Martinka, Gang Li

Alpha 1 antichymotrypsin is aberrantly expressed during melanoma progression and predicts poor survival for patients with metastatic melanoma 
Yang Wang, Helen Jiang, Derek Dai, Mingwan Su, Magdalene Martinka, Penny Brasher, Yaohua Zhang, David McLean, Junling Zhang, Wency Ip, Gang Li, Xuejun Zhang, Youwen Zhou

The quest for the melanoma stem cell: Still more questions than answers 
Florian Rambow, Lionel Larue

Genetic and Environmental Melanoma Models in Fish 
E. Elizabeth Patton, David L. Mitchell, Rodney S. Nairn

Growth and progression of melanoma and non-melanoma skin cancers regulated by ubiquitination
Koh Nakayama

Reactive Oxygen Species and Melanoma: An Explanation for Gender Differences in Survival? 
Arjen Joosse, Esther De Vries, Casper. H. van Eijck, Alexander M.M. Eggermont, Tamar Nijsten, Jan Willem W. Coebergh

Silencing and re-expression of retinoic acid receptor beta2 in human melanoma
Jun Fan, Linda Eastham, Melinda E. Varney, Adam Hall, Nicolas L. Adkins, Vincent E. Sollars, Philippe Georgel and Richard M. Niles

Inhibition of p38 MAPK enhances ABT-737-induced cell death in melanoma cell lines: novel regulation of PUMA 
Angela M. Keuling, Susan E. Andrew, Victor A. Tron

Human malignant melanoma harbours a large fraction of highly clonogenic cells that do not express markers associated with cancer stem cells 
Lina Prasmickaite, Nirma Skrbo, Hanne K. Høifødt, Zhenhe Suo, Olav Engebråten, Hans P. Gullestad, Steinar Aamdal, Øystein Fodstad, Gunhild M. Mælandsmo

Mutation spectrum of the first melanoma genome points finger firmly at ultraviolet light as the primary carcinogen
Nicholas K. Hayward

Roles of Endothelin Signaling in Melanocyte Development and Melanoma
Amy Saldana-Caboverde, Lidia Kos

Mutations in KIT occur at low frequency in melanomas arising from anatomical sites associated with chronic and intermittent sun exposure
Despina Handolias, Renato Salemi, William Murray, Angela Tan, Wendy Liu, Amaya Viros, Alexander Dobrovic, John Kelly, Grant A McArthur

Functional alterations in protein kinase C beta II expression in melanoma 
John P. Voris, Leonid A. Sitailo, Heidi R. Rahn, Ann Defnet, Aaron T. Gerds, Robert Sprague, Vipin Yadav, I. Caroline Le Poole, Mitchell F. Denning

PAX3 and SOX10 activate MET receptor expression in melanoma
Joseph B. Mascarenhas, Erica L. Littlejohn, Rebecca J. Wolsky, Kacey P. Young, Maria Nelson, Ravi Salgia, Deborah Lang

Dormancy of metastatic melanoma
Liliana Ossowski, Julio A. Aguirre-Ghiso

Molecular pathogenesis of malignant melanoma: a different perspective from the studies of melanocytic nevus and acral melanoma
Minoru Takata, Hiroshi Murata, Toshiaki Saida

ERK-regulated differential expression of the Mitf 6a/b splicing isoforms in melanoma
Aline Primot, Ariane Mogha, Sébastien Corre, Karen Roberts, Julien Debbache, Henri Adamski, Brigitte Dreno, Amir Khammari, Thierry Lesimple, Agnes Mereau, Colin R Goding, Marie-Dominique Galibert

AKT2 is a downstream target of metabotropic glutamate receptor 1 (Grm1)
Seung-Shick Shin, Brian A. Wall, James S. Goydos, Suzie Chen

High Molecular Weight−Melanoma-Associated Antigen as a Biomarker of Desmoplastic Melanoma
Yasufumi Goto, Takaaki Arigami, Rajmohan Murali, Richard A. Scolyer, Atsushi Tanemura, Minoru Takata, Roderick R. Turner, Linhda Nguyen, Tung Nguyen, Donald L. Morton, Soldano Ferone, Dave S.B. Hoon

The PGF2a receptor FP is lost in nevi and melanoma
Alex Fricke, Lindy McClelland, Glynis Scott



Mutated ERBB4: a novel drug target in metastatic melanoma?  
Kari Kurppa, Klaus Elenius

Involvement of ABC transporters in melanogenesis and the development of multidrug resistance of melanoma 
Kevin G. Chen, Julio C. Valencia, Jean-Pierre Gillet, Vincent J. Hearing, Michael M. Gottesman

SKI knockdown inhibits human melanoma tumor growth in vivo 
Dahu Chen, Qiushi Lin, Neil Box, Dennis Roop, Shunsuke Ishii, Koichi Matsuzaki, Tao Fang, Thomas J. Hornyak, Jon A Reed, Ed Stavnezer, Nikolai A. Timchenko and Estela E. Medrano

NRG1 / ERBB3 signaling in melanocyte development and melanoma: inhibition of differentiation and promotion of proliferation 
Kristina Buac, Mai Xu, Julie Cronin, Ashani T. Weeraratna, Stephen M. Hewitt, William J. Pavan

Identification of direct transcriptional targets of V600EBRAF/MEK signalling in melanoma 
Leisl M Packer, Philip East, Jorge S Reis-Filho, Richard Marais

Inhibition of Siah2 ubiquitin ligase by vitamin K3 (menadione) attenuates hypoxia and MAPK signaling and blocks melanoma tumorigenesis 
Meera Shah, John L. Stebbins, Antimone Dewing, Jianfei Qi, Maurizio Pellecchia, Ze'ev A. Ronai

Twenty-two cutaneous primary melanomas in a patient with high genetic predisposition to melanoma receiving levodopa therapy for Parkinson's disease 
Julie Charles, Isabelle Templier, Dominique Leroux, Dimitri Salameire, Caroline Robert, Sylvie Lantuejoul, Marie-Therese Leccia

Genome-wide associations studies for melanoma and nevi 
Iwei Yeh, Boris C. Bastian

Public health issues arising from sale of illegal and potentially unsafe ‘tanning chemicals’ 
Veronique Del Marmol, Thomas Luger, Norbert J. Neumann and Jean-Paul Ortonne

MITF pathway mutations in melanoma 
Satoru Yokoyama, Nunciada Salma, David E. Fisher

Use of liposomes as drug delivery vehicles for treatment of melanoma
Melissa A. Tran, Rebecca J. Watts, Gavin P. Robertson

The PTEN–AKT3 signaling cascade as a therapeutic target in melanoma 
SubbaRao V. Madhunapantula, Gavin P. Robertson

Frequent mutations in the MITF pathway in melanoma
Julia C. Cronin, John Wunderlich, Stacie K. Loftus, Todd D. Prickett, Xiaomu Wei, Katie Ridd, Swapna Vemula, Allison S. Burrell, Neena S. Agrawal, Jimmy C. Lin, Carolyn E. Banister, Phillip Buckhaults, Steven A. Rosenberg, Boris C. Bastian, William J. Pavan, Yardena Samuels

Inflammation and melanoma metastasis
Vladislava O. Melnikova, Menashe Bar-Eli

BI-69A11-mediated inhibition of AKT leads to effective regression of xenograft melanoma
Supriya Gaitonde, Surya K De, Marianna Tcherpakov, Antimone Dewing, Hongbin Yuan, Megan Riel-Mehan, Stan Krajewski, Gavin Robertson, Maurizio Pellecchia, Ze'ev Ronai

MC1R variation and melanoma risk in the Swedish population in relation to clinical and pathological parameters
Veronica Höiom, Rainer Tuominen, Max Käller, Diana Lindén, Afshin Ahmadian, Eva Månsson-Brahme, Suzanne Egyhazi, Klas Sjöberg, Joakim Lundeberg, Johan Hansson

Mouse pigmentation mutants help identify a uveal melanoma oncogene
Nicholas K. Hayward

Positive crosstalk between ERK and p38 in melanoma stimulates migration and in vivo proliferation
Yeriel Estrada, Jianli Dong, Liliana Ossowski

Inhibition of melanoma brain metastasis by targeting melanotransferrin at the cell surface
Yannève Rolland, Michel Demeule, Laurence Fenart, Richard Béliveau

Wild type and melanoma-associated mutant p16INK4a proteins do not oligomerize in vivo
Heather McKenzie, Therese M. Becker, Lyndee L. Scurr, Richard F. Kefford, Helen Rizos



Effectively targeting BRAF in melanoma: a formidable challenge
Leslie A Fecher, Ravi Amaravadi, Lynn M. Schuchter

All for one, one for all: alternative promoters and Mitf 
Eiríkur Steingrímsson

G-protein-coupled receptors and melanoma
Hwa Jin Lee, Brian Wall, Suzie Chen

JNK supports survival in melanoma cells by controlling cell cycle arrest and apoptosis
Vasileia-Ismini Alexaki, Delphine Javelaud, Alain Mauviel

A novel transport and delivery mechanism underpins the effectiveness of prolyl-m-sarcolysyl-p-fluorophenylalanine (PSF) in a human melanoma xenograft nude-mouse model
Karen ME Dierickx, Renato Morandini, Thi Hien Nguyen, François Salès, Jean-Michel Kauffmann, Ghanem E Ghanem

The antidepressant sertraline downregulates Akt and has activity against melanoma cells
Kalpana K. Reddy, Benjamin Lefkove, Jack L. Arbiser et al.

Pharmacologic suppression of MITF expression via HDAC inhibitors in the melanocyte lineage
Satoru Yokoyama, Erez Feige, Laura L. Poling, Carmit Levy, Hans R. Widlund, Mehdi Khaled, Andrew L. Kung, David E. Fisher

Dose-dependent, complete response to imatinib of a metastatic mucosal melanoma with a K642E KIT mutation
Jose Lutzky, Juergen Bauer, Boris C. Bastian

SKI is critical for repressing the growth inhibitory function of TGF-β in human melanoma
Jon A. Reed, D. Chen, Q. Lin, E. E. Medrano

How to make a melanoma: what do we know of the primary clonal events?
Dorothy C. Bennett
Pages 27-38
February 2008

Cancer stem cells and human malignant melanoma
Tobias Schatton and Markus H Frank
Pages 39-55
February 2008


The many faces of Notch signaling in skin-derived cells
Chelsea C. Pinnix and Meenhard Herlyn
Pages 458-465
December 2007

DNA microarray analyses of melanoma gene expression: a decade in the mines
Keith S. Hoek
Pages 466-484
December 2007

Cutaneous melanoma in genetically modified animals
Lionel Larue and Friedrich Beermann
Pages 485-497
December 2007

ATF2 on the double - activating transcription factor and DNA damage response protein
Anindita Bhoumik, Pablo Lopez-Bergami and Ze'ev Ronai
Pages 498-506
December 2007

Melanoma senescence: HDAC1 in focus
Colin R. Goding
Pages 336-338
October 2007

Potent p53-independent tumor suppressor activity of ARF in melanoma-genesis
Hans R. Widlund, David E. Fisher
Pages 339-340
October 2007

The HOG-GLI face of melanoma
Menashe Bar-Eli
Pages 341-342
October 2007

Detection of melanoma cells in sentinel lymph nodes by PCR is not yet ready for prime time
Paul B. Chapman
Pages 343-344
October 2007

Wnt5a and PKC, a deadly partnership involved in melanoma invasion
Estela E. Medrano
pages 258-259
August 2007

Melanoma invasion – current knowledge and future directions
Cedric Gaggioli and Erik Sahai
June 2007

Confirmation of a BRAF mutation-associated gene expression signature in melanoma
Peter Johansson, Sandra Pavey and Nicholas Hayward
June 2007

Molecular markers of circulating melanoma cells
Sandra Medic, Robert L. Pearce, Peter J. Heenan and Mel Ziman
pages 80-91
April 2007

Epigenetic events in malignant melanoma
Tanja Rothhammer and Anja-Katrin Bosserhoff
pages 92-111
April 2007

Loss of maspin expression contributes to a more invasive potential in malignant melanoma
Alexandra E. Denk, Marcus Bettstetter, Peter J. Wild, Keith Hoek, Frauke Bataille, Wolfgang Dietmaier and Anja K. Bosserhoff
pages 112-119
April 2007


Bioimmunotherapy for melanoma using fully human antibodies targeting MCAM/MUC18 and IL-8
Vladislava O. Melnikova, Menashe Bar-Eli
October 2006

Pocket protein function in melanocyte homeostasis and neoplasia
Ian D. Tonks, Nicholas K. Hayward, Graham F. Kay
August 2006

Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature
Keith S. Hoek, Natalie C. Schlegel, Patricia Brafford, Antje Sucker, Selma Ugurel, Rajiv Kumar, Barbara L. Weber, Katherine L. Nathanson, David J. Phillips, Meenhard Herlyn, Dirk Schadendorf, Reinhard Dummer
August 2006

NF-κB activation in melanoma
Yukiko Ueda, Ann Richmond
April 2006

Apaf-1 expression in human cutaneous melanoma progression and in pigmented nevi
Katarzyna Niedojad?o, Karolina ?abeodzka, Ewelina ?ada, Agnieszka Milewska, Barbara W. Chwirot
Katarzyna Niedojadlo, Karolina Labedzka, Ewelina Lada, Agnieszka Milewska, Barbara W. Chwirot
February 2006

Glutamate receptors on human melanocytes regulate the expression of MiTF
M. J. Hoogduijn, I. S. Hitchcock, N. P. M. Smit, J. M. Gillbro, K. U. Schallreuter, P. G. Genever
February 2006


Melanoma inhibitory activity (MIA): an important molecule in melanoma development and progression
Anja-Katrin Bosserhoff
December 2005

Adhesion, migration and communication in melanocytes and melanoma
Nikolas K. Haass, Keiran S. M. Smalley, Ling Li, Meenhard Herlyn
June 2005

Histone deacetylase inhibitors and malignant melanoma
Glen M. Boyle, Adam C. Martyn, Peter G. Parsons
June 2005

Original articles
Melanoma cell lines are susceptible to histone deacetylase inhibitor TSA provoked cell cycle arrest and apoptosis
Karita Peltonen, Taija M. Kiviharju, Päivi M. Järvinen, Runar Ra, Marikki Laiho
June 2005

Inhibition of melanoma inhibitory activity (MIA) expression in melanoma cells leads to molecular and phenotypic changes
Jutta Tatzel, Ina Poser, Josef Schroeder, Anja K Bosserhoff
April 2005

Principal expression of two mRNA isoforms (ABCB 5 and ABCB 5 ) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes
Kevin G. Chen, Gergely Szakács, Jean-Philippe Annereau, Francois Rouzaud, Xing-Jie Liang, Julio C. Valencia, Chandrasekharam N. Nagineni, John J. Hooks, Vincent J. Hearing, Michael M. Gottesman
April 2005

Decreased expression of Apaf-1 with progression of melanoma
Rita Mustika, Arief Budiyanto, Chikako Nishigori, Masamitsu Ichihashi, Masato Ueda
February 2005

Blackwell Publishing

Blackwell Publishing